Isothermal Titration Calorimetry (ITC) is a technique used in quantitative biomolecular interaction studies. It works by label-free directly measuring the heat that is either released or absorbed during a binding event enabling accurate determination of binding constants (KD), reaction stoichiometry (n), enthalpy (∆H) and entropy (ΔS). This provides a complete thermodynamic profile of the molecular interaction. ITC goes beyond binding affinities and can elucidate the mechanisms underlying molecular interactions.
This application can be used for studying interactions between:
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