Applications
From a global snapshot of hundreds of metabolites to a single chiral molecule, and from static levels to real-time fluxes in living cells.
Untargeted & profiling
Discover what changes, without deciding in advance what to look for.
Untargeted metabolomics
A global view of the metabolic phenotype, including unknown compounds. Ideal for generating hypotheses and spotting disrupted pathways.
Untargeted lipidomics
Broad lipid profiling across more than 25 lipid classes:
Phospholipids: cardiolipin, PA, PC, PE, PG, PI
Sphingolipids: ceramides, hexosylceramides, gangliosides, sphingomyelins
Neutral lipids and sterols: mono-, di- and triglycerides, cholesterol, cholesteryl esters
Fatty acyls and more: acylcarnitines, coenzyme Q, fatty acids
Polar metabolites profiling
Identification and relative quantification of up to 560 polar metabolites: glycolysis, TCA cycle, pentose phosphate, amino acids, nucleotides and more.
Secretomics
What cells take up from their medium and what they release into it: a direct readout of nutrient consumption and secretion.
Targeted assays
Accurate measurement of specific molecule families, chosen for your question.
Total and free fatty acids
Fatty acids in their free form, or the total pool released from complex lipids, with chain-length and saturation detail.
Short-chain fatty acids
Acetate, propionate, butyrate and related acids: key readouts of gut microbiome activity.
Steroids panel
Steroid hormones built on the four-ring sterol scaffold, measured together in one panel.
Bile acids panel
Primary, secondary and taurine- or glycine-conjugated bile acids, linking liver, gut and microbiome.
Chiral analysis
Telling mirror-image molecules apart: D/L-amino acids, D/L-lactate and D/L-2-hydroxyglutarate, which standard methods measure as one.
Polyamines
Putrescine, spermidine, spermine and their acetylated forms: regulators of cell growth, proliferation and aging.
Catecholamines
Dopamine, norepinephrine and epinephrine: neurotransmitters and stress hormones measured in tissue and biofluids.
Amino acids quantification
Absolute concentrations of amino acids, the building blocks of proteins and hubs of nitrogen and energy metabolism.
Custom assays
Don’t see your molecule? We develop new methods for compounds outside our standard panels.
Real-time metabolic analyses
Live-cell measurements of oxygen consumption and acidification on the Seahorse analyzer.
ATP production rate
How much ATP your cells make, and how much comes from mitochondria versus glycolysis.
Mitochondrial toxicity
Test whether drugs and compounds impair mitochondrial function, before it shows up as cell death.
Mitochondrial stress test
Basal and maximal respiration, spare capacity, ATP-linked respiration and proton leak, from one experiment.
Glycolytic rate
Real-time glycolysis from proton efflux: basal rate and how far cells can ramp it up when mitochondria are blocked.
Mitochondrial substrate oxidation
Which fuel your mitochondria depend on: glucose, glutamine or fatty acids, and how flexibly they switch.
Stable isotope tracing
Levels tell you how much. Tracing tells you how fast, and through which pathway.
We feed cells or animals a nutrient labeled with heavy carbon or nitrogen, then follow the labeled atoms through the metabolic network to measure pathway activity.
13C6-glucose1,2-13C2-glucose13C3-lactate13C5-glutamine13C5,15N2-glutamine13C16-palmitateand more
Not sure which application fits your question? We can help you choose.
