Ryvkin J, Omesi L, Kim Y K, Levi M, PozeiloLital Barak-Buchris L, Agranovich B, Abramovich I, Gottlieb E, Jacob A, Nässel D R, Heberlein U, Shohat-Ophir G

Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons
PLoS genetics, 20(1), e1011054, 2024

Ghrayeb A, Finney A C, Agranovich B, Peled D, Anand S K, McKinney M P, Sarji M, Yang D, Weissman N, Drucker S, Fernandes S I, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi P L, Traylor J, Zhang J, Abramovich I, Chen Y E, Rom O, Mor I, Gottlieb E

Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
Cell Metabolism, 36(1), 116-129, 2024

Radzishevsky I, Odeh M, Bodner O, Zubedat S, Shaulov L, Litvak M, Esaki K, Yoshikawa T, Agranovich B, Li WH, Radzishevsky A, Gottlieb E, Avital A, Wolosker H

Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction
Proceedings of the National Academy of Sciences, 120(42), e2302780120, 2023

Riahi Y, Kogot-Levin A, Kadosh L, Agranovich B, Malka A, Assa M, Piran R, Avrahami D, Glaser B, Gottlieb E, Jackson III F, Cerasi E, Bernal-Mizrachi E, Helman E, Leibowitz G

Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Diabetologia, 66(10), pp.1925-1942, 2023

Rein A, Geron I, Kugler E, Fishman H, Gottlieb E, Abramovich I, Giladi A, Amit I, Mulet-Lazaro R, Delwel R, Gröschel S

Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency.
Haematologica, 108(9), p.2316, 2023

Gea J, Enríquez-Rodríguez CJ, Agranovich B, Pascual-Guardia S

Update on metabolomic findings in COPD patients
ERJ Open Research, 9(5), 2023

Haran A, Bergel M, Kleiman D, Hefetz L, Israeli H, Weksler-Zangen S, Agranovich B, Abramovich I, Schyr RB, Gottlieb E, Ben-Zvi D

Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism
Iscience, 26(7), 2023

Katz S, Grajeda-Iglesias C, Agranovich B, Ghrayeb A, Abramovich I, Hilau S, Gottlieb E, Hershberg R

Metabolic adaptation to consume butyrate under prolonged resource exhaustion
PLoS genetics, 19(6), e1010812, 2023

Amleh A, Chen HP, Watad L, Abramovich I, Agranovich B, Gottlieb E, Ben-Dov IZ, Nechama M, Volovelsky O

Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
Cell Reports Medicine, 4(6), 2023

Zheng L, Zhu Z R, Sneh T, Zhang W T, Wang Z Y, Wu G Y, He W, Qi H G, Wang H, Wu X Y, Fernández-García J, Abramovich I, Xu Y Z, Zhang J, Gottlieb E

Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase–deficient renal cell carcinoma
The Journal of Clinical Investigation,133(11), 2023

Astre G, Atlan T, Goshtchevsky U, Oron-Gottesman A, Smirnov M, Shapira K, Velan A, Deelen J, Levy T, Levanon EY, Harel I

Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate
Developmental Cell, 58(15), 1350-1364, 2023

Sosnovski KE, Braun T, Amir A, Moshel D, BenShoshan M, VanDussen KL, Levhar N, Abbas-Egbariya H, Beider K, Ben-Yishay R, Asad Ali S, Moore S R, Kugathasan S, Abramovich I, Glick Saar E, Weiss B, Barshack I, Gottlieb E, Geiger T, Ben-Horin S, Ulitsky I, Hyams J S, Denson L A, Haberman Y

GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis
Journal of Crohn's and Colitis, 17(6), 960-971, 2023

Kogot-Levin A, Riahi Y, Abramovich I, Mosenzon O, Agranovich B, Kadosh L, Schyr RB, Kleiman D, Hinden L, Cerasi E, Ben-Zvi D, Bernal-Mizrachi E, Tam J, Gottlieb E, Leibowitz G

Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition
JCI insight, 8(7), 2023

Cohen LD, Ziv T, Ziv NE

Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points
Frontiers in Molecular Neuroscience, 15, 1038614, 2022

Ahmad M, Abramovich I, Agranovich B, Nemirovski A, Gottlieb E, Hinden L, Tam J

Kidney Proximal Tubule GLUT2—More than Meets the Eye
Cells, 12(1), 94, 2022

Willi L, Abramovich I, Fernandez-Garcia J, Agranovich B, Shulman M, Milman H, Baskin P, Eisen B, Michele DE, Arad M, Binah O, Gottlieb E

Bioenergetic and metabolic impairments in induced pluripotent stem cell-derived cardiomyocytes generated from Duchenne muscular dystrophy patients
International journal of molecular sciences, 23(17), 9808, 2022

Saragovi A, Zilberman T, Yasur G, Turjeman K, Abramovich I, Kuchersky M, Gottlieb E, Barenholz Y, Berger M

Analysis of cellular water content in T cells reveals a switch from slow metabolic water gain to rapid water influx prior to cell division
Journal of Biological Chemistry, 298(4), 2022

Saragovi A, Zheng X, Abramovich I, Cohen-Daniel L, Zhuoning L, Raifer H, Omar I, Swisa A, Kuchersky M, Drori A, Marini F, Toker O, Somech R, Schmidl C, Hendrickson R C, Gottlieb E, Huber M, Berger M

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation
bioRxiv, 2022-08, 2022

Tzukerman M, Shamai Y, Abramovich I, Gottlieb E, Selig S, Skorecki K

Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells
Cancers, 14(3), 733, 2022

Miskevich D, Chaban A, Dronina M, Abramovich I, Gottlieb E, Shams I

Glutamine homeostasis and its role in the adaptive strategies of the blind mole rat, Spalax
Metabolites, 11(11), 755, 2021

Miskevich D, Chaban A, Dronina M, Abramovich I, Gottlieb E, Shams I

Comprehensive analysis of 13C6 Glucose fate in the hypoxia-tolerant blind mole rat skin fibroblasts
Metabolites, 11(11), 734, 2021

Grima-Reyes M, Martinez-Turtos A, Abramovich I, Gottlieb E, Chiche J, Ricci JE

Physiological impact of in vivo stable isotope tracing on cancer metabolism
Molecular metabolism, 53, 101294, 2021

Khezri R, Holland P, Schoborg TA, Abramovich I, Takáts S, Dillard C, Jain A, O'Farrell F, Schultz SW, Hagopian WM, Quintana EM, Ng R, Katheder N S, Rahman M M, Teles Reis J G, Brech A, Jasper H, Rusan N M, Jahren A H, Gottlieb E, Rusten T E

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
The EMBO Journal, 40(18), e107336., 2021

Saragovi A, Abramovich I, Omar I, Arbib E, Toker O, Gottlieb E, Berger M

Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest
Elife, 9, e5661, 2021

Roichman A, Elhanati S, Aon MA, Abramovich I, Di Francesco A, Shahar Y, Avivi MY, Shurgi M, Rubinstein A, Wiesner Y, Shuchami A, Petrover Z, Lebenthal-Loinger I, Yaron O, Lyashkov A, Ubaida-Mohien C, Kanfi Y, Lerrer B, Fernández-Marcos PJ, Serrano M, Gottlieb E, Cabo R De, Cohen HY

Restoration of energy homeostasis by SIRT6 extends healthy lifespan
Nat Commun 12: 3208, 2021

Luna-Yolba R, Marmoiton J, Gigo V, Marechal X, Boet E, Sahal A, Alet N, Abramovich I, Gottlieb E, Visentin V, Paillasse MR, Sarry JE

Disrupting mitochondrial electron transfer chain complex I decreases immune checkpoints in murine and human acute myeloid leukemic cells
Cancers, 13(14), 3499, 2021

Savino AM, Fernandes SI, Olivares O, Zemlyansky A, Cousins A, Markert EK, Barel S, Geron I, Frishman L, Birger Y, Eckert C, Tumanov T, MacKay G, Kamphorst J J, Herzyk P, Fernández-García J,Abramovich I, Mor I, Bardini M, Barin E, Janaki-Raman S, Cross J R, Kharas M G, Gottlieb E, Izraeli S, Halsey C

Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase
Nature cancer, 1(10), 998-1009, 2020

Drabkin M, Yogev Y, Zeller L, Zarivach R, Zalk R, Halperin D, Wormser O, Gurevich E, Landau D, Kadir R, Perez Y, Birk O S

Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase
The Journal of clinical investigation, 129(12), 5163-5168, 2019

Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, Gertler AA, Doniger T, Ilkayeva O R, Abramovich I, Yaron O, Lerrer B, Gottlieb E, Harris R A, Gerber D, Hirschey M D, Cohen H Y

SIRT6 promotes hepatic beta-oxidation via activation of PPARα
Cell reports, 29(12), 4127-4143, 2019

Savino AM, Olivares O, Barel S, Yakimov L, Geron I, Fishman H, Mor I, Abramovich I, Fernandes SI, Gottlieb E, Halsey C

Stearoyl-CoA desaturase (SCD) enhances central nervous system leukemia
Blood, 132, 389, 2018

Altshuler A, Verbuk M, Bhattacharya S, Abramovich I, Haklai R, Hanna JH, Kloog Y, Gottlieb E, Shalom-Feuerstein R

RAS regulates the transition from naive to primed pluripotent stem cells
Stem cell reports, 10(3), 1088-1101, 2018