The Laura and Isaac Perlmutter Metabolomics Center

The Laura and Isaac Perlmutter Metabolomics Center was established through a generous donation from the Laura and Isaac Perlmutter Foundation. The Foundation is dedicated to improving the lives of others – with a particular focus on health care, social justice, the arts and community initiatives.

The Metabolomics Center supports metabolism-focused research through measurements of small molecules in diverse biological samples, alongside assessments of oxidative phosphorylation, glycolysis and other energy metabolism processes in live cells. These complementary methodologies enable a comprehensive understanding of metabolic processes.

The center operates on a collaborative model in which we actively train the users in experimental design, sample preparation and data analysis, all tailored to each study. We believe in creating a mutual language with collaborators, providing our broad support for research projects at all stages.

We work with a wide range of sample types, including (but not limited to) cells, tissues, and biological fluids (blood, urine, saliva, CSF) from human subjects, research animals, or other organisms.

The center offers a variety of well-established methods for both targeted and untargeted metabolomic assays using state-of-the-art analytical instrumentation as well as method development to extend the center’s capabilities.

To achieve this successfully, we offer comprehensive metabolomics training that covers all aspects of experimental design, sample preparation, technological principles and data analysis.The center has established a unique feature whereas users around the country/world can access remotely their raw data, process and analyze it using our software to maximize the output of the facility. Visit our data analysis tutorials page.

Compounds of interest:

We carry out Hilic chromatography using Orbitrap Explorer 240 and Q Exactive. At present we can identify around 600 polar compounds. See the list here. The facility also carry out method development, including detection of unusual compounds, chiral molecules and fatty acids.

Please contact Prof. Herman Wolosker to consult for a new experiment.