Publications
Oz S, Saar G, Olszakier S, Heinrich R, Kompanets MO, Berlin S
Revealing the MRI‐Contrast in Optically Cleared Brains
Advanced Science. 2024 Apr 22:2400316, 2024
Ghrayeb A, Finney A C, Agranovich B, Peled D, Anand S K, McKinney M P, Sarji M, Yang D, Weissman N, Drucker S, Fernandes S I, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi P L, Traylor J, Zhang J, Abramovich I, Chen Y E, Rom O, Mor I, Gottlieb E
Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
Cell Metabolism, 36(1), 116-129, 2024
Ye J, Salti T, Zanditenas E, Trebicz-Geffen M, Benhar M, Ankri S
Impact of Reactive Sulfur Species on Entamoeba histolytica: Modulating Viability, Motility, and Biofilm Degradation Capacity
Antioxidants 13(2):245, 2024
Ryvkin J, Omesi L, Kim Y K, Levi M, PozeiloLital Barak-Buchris L, Agranovich B, Abramovich I, Gottlieb E, Jacob A, Nässel D R, Heberlein U, Shohat-Ophir G
Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons
PLoS genetics, 20(1), e1011054, 2024
Tiwari A, Haj N, Elgrably B, Berihu M, Laskov V, Barash S, Zigron S, Sason H, Shamay Y, Karni-Ashkenazi S, Holdengreber M, Saar G, Vandoorne K
Cross-Modal Imaging Reveals Nanoparticle Uptake Dynamics in Hematopoietic Bone Marrow during Inflammation
ACS Nano 18:7098–7113, 2024
Jadon J, Yelin R, Arraf AA, Asleh MA, Zaher M, Schultheiss TM
Regulation of aortic morphogenesis and VE-cadherin dynamics by VEGF
Developmental Biology. May 1;497:1-0., 2023
Zanditenas E, Trebicz-Geffen M, Kolli D, Domínguez-García L, Farhi E, Linde L, Romero D, Chapman M, Kolodkin-Gal I, Ankri S
Digestive exophagy of biofilms by intestinal amoeba and its impact on stress tolerance and cytotoxicity
npj Biofilms and Microbiomes 9(1):77, 2023
Rein A, Geron I, Kugler E, Fishman H, Gottlieb E, Abramovich I, Giladi A, Amit I, Mulet-Lazaro R, Delwel R, Gröschel S
Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency.
Haematologica, 108(9), p.2316, 2023
Radzishevsky I, Odeh M, Bodner O, Zubedat S, Shaulov L, Litvak M, Esaki K, Yoshikawa T, Agranovich B, Li WH, Radzishevsky A, Gottlieb E, Avital A, Wolosker H
Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction
Proceedings of the National Academy of Sciences, 120(42), e2302780120, 2023
Riahi Y, Kogot-Levin A, Kadosh L, Agranovich B, Malka A, Assa M, Piran R, Avrahami D, Glaser B, Gottlieb E, Jackson III F, Cerasi E, Bernal-Mizrachi E, Helman E, Leibowitz G
Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Diabetologia, 66(10), pp.1925-1942, 2023
Gea J, Enríquez-Rodríguez CJ, Agranovich B, Pascual-Guardia S
Update on metabolomic findings in COPD patients
ERJ Open Research, 9(5), 2023
Haran A, Bergel M, Kleiman D, Hefetz L, Israeli H, Weksler-Zangen S, Agranovich B, Abramovich I, Schyr RB, Gottlieb E, Ben-Zvi D
Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism
Iscience, 26(7), 2023
Katz S, Grajeda-Iglesias C, Agranovich B, Ghrayeb A, Abramovich I, Hilau S, Gottlieb E, Hershberg R
Metabolic adaptation to consume butyrate under prolonged resource exhaustion
PLoS genetics, 19(6), e1010812, 2023
Amleh A, Chen HP, Watad L, Abramovich I, Agranovich B, Gottlieb E, Ben-Dov IZ, Nechama M, Volovelsky O
Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
Cell Reports Medicine, 4(6), 2023
Zheng L, Zhu Z R, Sneh T, Zhang W T, Wang Z Y, Wu G Y, He W, Qi H G, Wang H, Wu X Y, Fernández-García J, Abramovich I, Xu Y Z, Zhang J, Gottlieb E
Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase–deficient renal cell carcinoma
The Journal of Clinical Investigation,133(11), 2023
Astre G, Atlan T, Goshtchevsky U, Oron-Gottesman A, Smirnov M, Shapira K, Velan A, Deelen J, Levy T, Levanon EY, Harel I
Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate
Developmental Cell, 58(15), 1350-1364, 2023
Sosnovski KE, Braun T, Amir A, Moshel D, BenShoshan M, VanDussen KL, Levhar N, Abbas-Egbariya H, Beider K, Ben-Yishay R, Asad Ali S, Moore S R, Kugathasan S, Abramovich I, Glick Saar E, Weiss B, Barshack I, Gottlieb E, Geiger T, Ben-Horin S, Ulitsky I, Hyams J S, Denson L A, Haberman Y
GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis
Journal of Crohn's and Colitis, 17(6), 960-971, 2023
Kogot-Levin A, Riahi Y, Abramovich I, Mosenzon O, Agranovich B, Kadosh L, Schyr RB, Kleiman D, Hinden L, Cerasi E, Ben-Zvi D, Bernal-Mizrachi E, Tam J, Gottlieb E, Leibowitz G
Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition
JCI insight, 8(7), 2023
Tzukerman M, Shamai Y, Abramovich I, Gottlieb E, Selig S, Skorecki K
Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells
Cancers. Jan 30;14(3):733, 2022
Abu-Tayeh Suleiman H, Said S, Ali Saleh H, Gamliel-Lazarovich A, Haddad E, Minkov I, Zohar Y, Ilan N, Vlodavsky I, Abassi Z, Assady S
Heparanase Increases Podocyte Survival and Autophagic Flux after Adriamycin-Induced Injury
International Journal of Molecular Sciences. Oct 21;23(20):12691, 2022
Kruzel-Davila E, Bavli-Kertselli I, Ofir A, Cheatham AM, Shemer R, Zaknoun E, Chornyy S, Tabachnikov O, Davis SE, Khatua AK, Skorecki K
Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity
Iscience. Jan 21;25(1)., 2022
Asleh MA, Zaher M, Jadon J, Shaulov L, Yelin R, Schultheiss TM
A Morphogenetic Wave that Generates Mesenchymal-to-Epithelial Transition in the Lateral Plate Mesoderm
bioRxiv. Mar 1:2022-03., 2022
Abd Elghani F, Safory H, Hamza H, Savyon M, Farhoud M, Toren‐Hershoviz M, Vitic Z, Ebanks K, Shani V, Bisharat S, Shaulov L, Brodski C, Song Zh, Bandopadhyay R, Engelender S
SIAH proteins regulate the degradation and intra‐mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson’s disease.
Aging Cell. Dec;21(12):e13731, 2022
Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender … See fewer authors
Cohen LD, Ziv T, Ziv NE
Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points
Frontiers in Molecular Neuroscience, 15, 1038614, 2022
Ahmad M, Abramovich I, Agranovich B, Nemirovski A, Gottlieb E, Hinden L, Tam J
Kidney Proximal Tubule GLUT2—More than Meets the Eye
Cells, 12(1), 94, 2022
Willi L, Abramovich I, Fernandez-Garcia J, Agranovich B, Shulman M, Milman H, Baskin P, Eisen B, Michele DE, Arad M, Binah O, Gottlieb E
Bioenergetic and metabolic impairments in induced pluripotent stem cell-derived cardiomyocytes generated from Duchenne muscular dystrophy patients
International journal of molecular sciences, 23(17), 9808, 2022
Saragovi A, Zilberman T, Yasur G, Turjeman K, Abramovich I, Kuchersky M, Gottlieb E, Barenholz Y, Berger M
Analysis of cellular water content in T cells reveals a switch from slow metabolic water gain to rapid water influx prior to cell division
Journal of Biological Chemistry, 298(4), 2022
Saragovi A, Zheng X, Abramovich I, Cohen-Daniel L, Zhuoning L, Raifer H, Omar I, Swisa A, Kuchersky M, Drori A, Marini F, Toker O, Somech R, Schmidl C, Hendrickson R C, Gottlieb E, Huber M, Berger M
Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation
bioRxiv, 2022-08, 2022
Tzukerman M, Shamai Y, Abramovich I, Gottlieb E, Selig S, Skorecki K
Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells
Cancers, 14(3), 733, 2022
Hajjo H, Bhardwaj N, Gefen T, Geva-Zatorsky N
Combinatorial click chemistry labeling to study live human gut-derived microbiota communities
Frontiers in Microbiology. Oct 27;12:750624., 2021
Miskevich D, Chaban A, Dronina M, Abramovich I, Gottlieb E, Shams I
Glutamine homeostasis and its role in the adaptive strategies of the blind mole rat, Spalax
Metabolites, 11(11), 755, 2021
Miskevich D, Chaban A, Dronina M, Abramovich I, Gottlieb E, Shams I
Comprehensive analysis of 13C6 Glucose fate in the hypoxia-tolerant blind mole rat skin fibroblasts
Metabolites, 11(11), 734, 2021
Grima-Reyes M, Martinez-Turtos A, Abramovich I, Gottlieb E, Chiche J, Ricci JE
Physiological impact of in vivo stable isotope tracing on cancer metabolism
Molecular metabolism, 53, 101294, 2021
Khezri R, Holland P, Schoborg TA, Abramovich I, Takáts S, Dillard C, Jain A, O'Farrell F, Schultz SW, Hagopian WM, Quintana EM, Ng R, Katheder N S, Rahman M M, Teles Reis J G, Brech A, Jasper H, Rusan N M, Jahren A H, Gottlieb E, Rusten T E
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
The EMBO Journal, 40(18), e107336., 2021
Saragovi A, Abramovich I, Omar I, Arbib E, Toker O, Gottlieb E, Berger M
Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest
Elife, 9, e5661, 2021
Roichman A, Elhanati S, Aon MA, Abramovich I, Di Francesco A, Shahar Y, Avivi MY, Shurgi M, Rubinstein A, Wiesner Y, Shuchami A, Petrover Z, Lebenthal-Loinger I, Yaron O, Lyashkov A, Ubaida-Mohien C, Kanfi Y, Lerrer B, Fernández-Marcos PJ, Serrano M, Gottlieb E, Cabo R De, Cohen HY
Restoration of energy homeostasis by SIRT6 extends healthy lifespan
Nat Commun 12: 3208, 2021
Yatchenko Y, Ben-Shachar D
Update of Mitochondrial Network Analysis by Imaging: Proof of Technique in Schizophrenia
In: Weissig V, Edeas M (eds) Mitochondrial Medicine. Methods in Molecular Biology, vol 2277. Humana, New York, NY, 2021
Schiller M, Azulay-Debby H, Boshnak N, Elyahu Y, Korin B, Ben-Shaanan TL, Koren T, Krot M, Hakim F, Rolls A
Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation
Immunity. May 11;54(5):1022-36., 2021
Kellner S, Abbasi A, Carmi I, Heinrich R, Garin-Shkolnik T, Hershkovitz T, Giladi M, Haitin Y, Johannesen KM, Steensbjerre Møller R, Berlin S
Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy
Elife. Jul 2;10:e67555, 2021
Yaseen W, Kraft-Sheleg O, Zaffryar-Eilot S, Melamed S, Sun C, Millay DP, Hasson P
Fibroblast fusion to the muscle fiber regulates myotendinous junction formation
Nature Communications. Jun 22;12(1):3852., 2021
Fares B, Berger L, Bangiev-Girsh E, Kakun RR, Ghannam-Shahbari D, Tabach Y, Zohar Y, Gottlieb E, Perets R
PAX8 plays an essential antiapoptotic role in uterine serous papillary cancer
Oncogene. Aug 26;40(34):5275-85., 2021
Luna-Yolba R, Marmoiton J, Gigo V, Marechal X, Boet E, Sahal A, Alet N, Abramovich I, Gottlieb E, Visentin V, Paillasse MR, Sarry JE
Disrupting mitochondrial electron transfer chain complex I decreases immune checkpoints in murine and human acute myeloid leukemic cells
Cancers, 13(14), 3499, 2021
Savino AM, Fernandes SI, Olivares O, Zemlyansky A, Cousins A, Markert EK, Barel S, Geron I, Frishman L, Birger Y, Eckert C, Tumanov T, MacKay G, Kamphorst J J, Herzyk P, Fernández-García J,Abramovich I, Mor I, Bardini M, Barin E, Janaki-Raman S, Cross J R, Kharas M G, Gottlieb E, Izraeli S, Halsey C
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase
Nature cancer, 1(10), 998-1009, 2020
Arraf AA, Yelin R, Reshef I, Jadon J, Abboud M, Zaher M, Schneider J, Vladimirov FK, Schultheiss TM
Hedgehog signaling regulates epithelial morphogenesis to position the ventral embryonic midline
Developmental Cell. Jun 8;53(5):589-602, 2020
Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, Gertler AA, Doniger T, Ilkayeva O R, Abramovich I, Yaron O, Lerrer B, Gottlieb E, Harris R A, Gerber D, Hirschey M D, Cohen H Y
SIRT6 promotes hepatic beta-oxidation via activation of PPARα
Cell reports, 29(12), 4127-4143, 2019
Drabkin M, Yogev Y, Zeller L, Zarivach R, Zalk R, Halperin D, Wormser O, Gurevich E, Landau D, Kadir R, Perez Y, Birk O S
Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase
The Journal of clinical investigation, 129(12), 5163-5168, 2019
Altshuler A, Verbuk M, Bhattacharya S, Abramovich I, Haklai R, Hanna JH, Kloog Y, Gottlieb E, Shalom-Feuerstein R
RAS regulates the transition from naive to primed pluripotent stem cells
Stem cell reports, 10(3), 1088-1101, 2018
Savino AM, Olivares O, Barel S, Yakimov L, Geron I, Fishman H, Mor I, Abramovich I, Fernandes SI, Gottlieb E, Halsey C
Stearoyl-CoA desaturase (SCD) enhances central nervous system leukemia
Blood, 132, 389, 2018
